Chlorpromazine in dystonic reactions.

Prolonged dystonic reaction to chlorpromazine in myxoedema coma.

A case of myxoedema coma is reported where the administration of chlorpromazine resulted in a prolonged dystonic reaction. A similar challenge with a butyrophenone when the patient was on thyroxine caused a similar but much abbreviated response.

Dystonic reactions to phenothiazine derivatives.

Phenothiazine derivatives are widely used and their toxic effects in adults are well recognized. They include dizziness, mild skin reactions, jaundice, motor restlessness, and occasionally neuromuscular reactions. Dystonia and symptoms resembling parkinsonism usually occur only at high dosages. These are well-recognized complications in mental hospitals when drugs are being used to treat psycho...

Dystonic reactions to metoclopramide (maxolon).

METOCLOPRAMIDE has been used in the treatment of various gastro-intestinal disorders for over a decade. Dystonic reactions to metoclopramide have been reported previously by Casteels-Van Daele et al (1970) and also Witzel (1968). The symptoms of dystonia appeared in their patients following the administration of metoclopramide in doses exceeding 0.5 mg/kg body weight for longer than a 24-hour p...

Dystonic reactions in children caused by metoclopramide.

Novel antipsychotics and acute dystonic reactions.

The growing use of atypical antipsychotics has led to a decrease of acute dystonic reactions (ADR). To evaluate the prevalence of ADR, we recorded all ADR occurring in a population of patients consecutively admitted to a psychiatric intensive care unit. Among 1337 cases treated with antipsychotics, we observed 41 cases (3.1%) affected by ADR. At discharge, mean chlorpromazine-equivalent daily d...